Animec Horse wormer (Ivermectin)

Animec Horse Wormer (Ivermectin) is an oral paste wormer for horses containing ivermectin as it's active ingredient. Animec treats a range of internal parasites, including small and large redworms, lungworms, pinworms and bots in horses.

Active Ingredient: Ivermectin

Target Species: Horse

Treats and Controls: Gastro-intestinal worms, lungworms, nasal bots

Administration Method: Oral paste

Withdrawal Time: Withdrawal period for meat and offal is 34 days. Do not use in mares producing milk for human consumption. Animec can be given to mares at any stages of pregnancy or lactation.

Dosage for Horses: Each syringe is sufficient to dose a horse up to 700kg. 

Always read the label and all enclosed information for Animec horse wormer before administering to animals!

Click here to Download Data Sheet

Health Products Regulatory Authority

Summary of Product Characteristics

1 NAME OF THE VETERINARY MEDICINAL PRODUCT
Animec 18.7 mg/g Oral Paste for Horses

2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Active substance:
Ivermectin  18.7 mg/g

Excipient(s):
For a full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM
Oral Paste
A white homogeneous paste

4 CLINICAL PARTICULARS
4.1 Target Species
Horses.

4.2 Indications for use, specifying the target species
Treatment of nematode or arthropod infection due to:
Large strongyles:
Strongylus vulgaris (adults and L4 stage larvae [arterial])
Strongylus edentatus (adults and L4 stage larvae [tissue])
Strongylus equinus (adults)

Small strongyles (including benzimidazole resistant strains):
Cyathostomum spp (adults and luminal L4 stage larvae)
Cylicocyclus spp. (adults and luminal L4 stage larvae)
Cylicodontophorus spp. (adults and luminal L4 stage larvae)
Cylicostephanus spp. (adults and luminal L4 stage larvae)
Gyalocephalus spp. (adults and luminal L4 stage larvae)
Ascarids: Parascaris equorum (luminal L5 larvae and adults)

Pinworms:
Oxyuris equi (L4 stage larvae and adults)

Neck threadworms:
Onchocerca spp (microfilariae)

Stomach bots:
Gasterophilus spp (oral and gastric stages)

4.3 Contraindications
Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Do not use in dogs or cats as severe adverse reactions may occur. 

4.4 Special warnings for each target species
Some horses with heavy infections of Onchocerca spp. microfilariae have experienced oedema and pruritus following treatment, such reactions are assumed to be the result of death of large numbers of microfilariae.
These signs resolve within a few days but symptomatic treatment may be advisable.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
· Too frequent and repeated use of anthelmintics from the same class over an extended period of time,
· Underdosing, which may be due to underestimation of body weight or misadministration of the product.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Veterinary advice should be given on appropriate dosing programs and stock management to achieve adequate parasite control and reduce the likelihood of anthelmintic resistance developing. 
In the event that a product is suspected of being ineffective, the animal owner is advised to seek veterinary advice. Resistance to ivermectin has been reported in Parascaris equorum.
Therefore, the use of this product should be based on local farm epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

4.5 Special precautions for use
Special precautions for use in animals
Since ivermectin is highly bound to plasma proteins, special care should be taken in cases of sick animals or in nutritional conditions associated with low plasma protein levels.
Dogs and cats should not be allowed to ingest spilled gel or have access to used packaging due to the potential for adverse effects related to ivermectin toxicity
The product has been formulated for use in horses only. Cats, dogs (especially Collies, Old English Sheepdogs and related breeds or crosses) and also turtles and tortoises may be adversely affected by the concentration of ivermectin in this product if they are allowed to ingest spilled paste or have access to used syringes.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Do not smoke, eat or drink while handling the product.
Wash hands after use.
This product may cause skin and eye irritation.
Therefore, the user should avoid contact of the product with the skin and the eyes.
In case of contact, rinse immediately with plenty of water.
In the case of accidental ingestion or eye irritation after contact seek medical advise immediately and show the package insert or the label to the physician

4.6 Adverse reactions (frequency and seriousness)
None known.

4.7 Use during pregnancy, lactation or lay
The product can be administered to mares at any stages of pregnancy or lactation.
Do not use in mares producing milk for human consumption.

4.8 Interaction with other medicinal products and other forms of interactions
The effects of GABA agonists are increased by ivermectin.

4.9 Amounts to be administered and administration route
Dosage:
One syringe division of paste per 100 kg body weight (based on a recommended dosage of 200 μg ivermectin per kg body weight).
The syringe containing 6.42 g of paste delivers sufficient paste to treat 600 kg of bodyweight at the recommended dose rate.
The syringe containing 7.49 g of paste delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate. Administration:
The paste is given by oral route.
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
The animal's mouth should be free from food to ensure swallowing. 
Turn the screw gauge on the syringe plunger to the body weight of the horse. 
The tip of the syringe barrel should be inserted at the interdental space (the gap between the front and back teeth) and the paste deposited on the base of the tongue.
Advance the plunger as far as it will go, depositing the medication on the base of the tongue.
Immediately elevate the horse's head for a few seconds to ensure swallowing.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Mild transitory signs (slowed pupillary light response and depression) have been seen at a higher dose of 1.8 mg/kg (9 times the recommended dose level).
Other signs seen at higher doses include mydriasis, ataxia, tremors, stupor, coma and death.
The less severe signs have been transitory.
Although no antidote has been identified, symptomatic therapy may be beneficial.

4.11 Withdrawal period(s)
Meat and offal: 34 days
Do not use in mares producing milk for human consumption.

5 PHARMACOLOGICAL or IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group:
Endectocide, macrocyclic lactones

ATCvet code:
QP54AA01

5.1 Pharmacodynamic properties
Ivermectin is a member of the macrocyclic lactone class of endectocides.
Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, which results in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels, and macrocyclic lactones do not readily cross the blood-brain barrier.

5.2 Pharmacokinetic particulars
Following oral administration of the recommended dose to horses, a mean peak plasma concentration (Cmax) of 33 ng/ml was achieved within 24 hours.
Ivermectin is well absorbed into the systemic circulation following administration.
Only about 2% of the drug is excreted in urine, faecal excretion being the major route of elimination. Ivermectin passes readily into milk.

6 PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Hydrogenated Castor Oil
Hydroxypropylcellulose
Titanium Dioxide (E171)
Propylene Glycol

6.2 Major incompatibilities
None known.

6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
The product is for single use. After use, the syringe should be discarded.

6.4 Special precautions for storage
Do not store above 25ºC

6.5 Nature and composition of immediate packaging
High density polyethylene dose graduated syringes in an outer cardboard box.
Pack size: Box containing 1 syringe of 6.42 g
                 Box containing 1 syringe of 7.49 g
                 Box containing 50 syringes of 7.49 g
Not all pack sizes may be marketed

6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
EXTREMELY DANGEROUS TO FISH AND AQUATIC LIFE.
Do not contaminate surface waters or ditches with product or used container.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

7 MARKETING AUTHORISATION HOLDER
ECO Animal Health Europe Limited
6th Floor
South Bank House
Barrow Street
Dublin 4
D04 TR29
Ireland
 

8 MARKETING AUTHORISATION NUMBER(S)
VPA22693/008/001

9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
Date of first authorisation: 10 November 2006
Date of last renewal: 10 November 2016 

10 DATE OF REVISION OF THE TEXT
March 201

Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis. 
Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl) avermectin A1a (22,23-dihydroavermectin B1b).

Delivery Information

Delivery Service

Here at Agridirect we have joined forces with DPD to ensure all packages are delivered promptly and safely to you. We ship to all mainland countries within the EU. Deliveries take place Monday to Friday excluding bank holidays. Once your order has been dispatched from our warehouse you will be notified by email. If there is a delay with your order for any reason you will be contacted immediately. 

Due to Brexit we are temporarily unable to ship to the UK. Shipping to Northern Ireland will remain in place.

Delivery Times

Some products have an extended delivery time, this is noted on the products.

Delivery Rates

A selection of the products we sell are only licensed for sale within the Republic Of Ireland and can not be shipped outside of the country. These products are noted as only being available within the Republic of Ireland on the individual product pages.

There may be an addition charge on certain bulky items. This charge will be clearly marked on an applicable products and will be explained on the checkout page before payment has been made.

Agridirect Returns Policy

We’re sorry your purchase didn’t work out. But don’t worry; we have a great returns policy to help you out.

All purchases can be returned to us within 14 days of delivery and returned goods must be received within 14 days from the date you informed us of the return.

Purchases may be opened for inspection but must not be used and must be repackaged securely in the original packaging if you wish to return it.

If we discover goods have been used or there has been a loss in value of the goods due to damage to the goods, while in your care or whilst being returned to us, we will reduce the amount refunded, which may amount to the full cost of the product, to cover loss of value of goods.

All returns should be complete which includes boxes, manuals and accessories that may have been included with the order.

All returns must be packaged appropriately for shipping, we will not accept responsibility for damages or loss which occur during shipping of a return product.

We accept no responsibility for goods damaged or lost while in transit to us. 

How do I return a product?

We have partnered with DPD to make your returns process easy and secure. simply follow the steps below and bring your package to an official DPD pickup point.

1) All returns must be accompanied with a fully filled out returns form which can be downloaded here.

2) To print off your return label click here or visit www.dpd.ie/returns and follow the on-screen instructions. Make sure and use your order number as your reference.

• Select “Continue as Guest”
• Select “Agridirect” from the drop-down menu
• Select your reason for returning
• Select the size of the package you wish to return
• Accept DPD’s terms and conditions
• Fill in your payment details
• Fill in your own details
• Follow the instructions to print off your label

3) Bring your package to a DPD pickup point. To find your nearest drop off point here.

Once the returned product has been received into our warehouse and been fully inspected a refund will be issued.

If you choose not to use the DPD returns service we recommend that you use a method that can be tracked.

For the return of bulk products please contact us at sales@agridirect.ie

I have received a damaged product from you, what should I do?

First off, if you have received a damaged electrical product from us, do not plug it in. Any electrical products that are plugged in are deemed ‘as used and accepted’ and are not accepted as returns. All damages must be reported to us via phone or email within 24hours of receipt of goods. Please ensure you check your items upon delivery.

How do I begin the returns process?

If you wish to begin the return process, please email us at sales@agridirect.ie and ensure the following information is included in your email. Your name, phone number, Order id, the item you wish to return, reason for return and if the product is damaged we require photos of the product.

Once you have sent us all required information a member of our team will assess your claim and will contact you as soon as possible. Please hold off on returning products until a member of our team has called you to confirm.

Refunds

Once the returned product has been returned to us and fully inspected a refund will be issued.

Please Note: A typical timeline for a refund to show in your account is up to 10 working days from the date processed, depending on your bank.